ABSTRACT
Objective To investigate the impact and the associated parameters of malnutrition and inflammation status on hospitalization and mortality of maintenance hemodialysis (MHD) patients. Method A total of 118 MHD patients were included in the study with 1 year's follow-up.The malnutrition and inflammation parameters were compared between the hospitalized patients and out-patients.Cox's proportional hazard regression model was used to explore the malnutrition and inflammation parameters which could forecast the risk of hospitalization and mortality. Result The hospitalization rate of MHD patients with mild,moderate and severe malnuttition was 32.93％,56.67％ and 83.33％ respectively,and the mortality was 3.66％,6.67％ and 80.00％ respectively.The hospitalization rate of MHD patients with or without microinflammation status was 56.45％ and 46.43％,and the mortality was 14.29％ and 1.61％.Inpatients had a higher malnutrition-inflammation score(MIS,8.36 vs 5.86,P＜0.05) and subjective global assessment of nutrition (MQSGA,14.49 vs 12.88,P＜0.05),a lower creatinine level (886.83 μmol/L vs 991.76 μmol/L,P＜0.05 ) and a lower albumin level (38.57 g/L vs 40.27 g/L,P＜0.05) than out-patients.Inpatients also had a higher level of TNF-α (65.41 μg/L vs 59.76 μg/L,P＜0.05) than out-patients.Cox proportional hazard model analysis showed that MIS and TNF-α were associated with patient's first hospitalization risk. Conclusions For the MHD patients,the more severe the malnutrition and micro-inflammation status is,the worse the clinical outcome is.The higher levels of MIS and TNF-α result in greater risk of hospitalization.
ABSTRACT
The authors analyzed the status quo of the indicators, outcomes and uses,methodology, procedures and technologies of the variations management of clinical pathways in China the abroad. The outputs of the study point to the following assignments in such a management, such as further identification of the contents of such variations, and further clarification of variation analysis indicators.
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<p><b>OBJECTIVE</b>To study the chemical constituents of Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell.</p><p><b>METHOD</b>The compounds were isolated by column chromatography with silica gel, C18 reverse-phase silica gel, sephadex LH-20, and their structures were elucidated on the basis of physiochemical propertities and spectral analysis. The antitumor activities of all compounds were tested with MOLT4, Hep G2, A-549, MCF-7, HT-29, PC-3 tumor cell lines.</p><p><b>RESULT</b>Five compounds were isolated and identified as protoapigenone (1), protoapigenin (2), protoapigenin-4'-O-beta-D-glucopyanoside (3), 5,7-dihydroxy-2-(1,2-isopropyldioxy-4-oxo-cyclohex-5-enyl) -chromen-4-one (4), 5,7-dihydroxy-2-(1-hydroxy-2,6-dimethoxy-cyclohex-4-oxo) -chromen-4-one (5), respectively.</p><p><b>CONCLUSION</b>All compounds were obtained from this plant for the first time. Compounds 1, 4 and 5 showed strong anti-proliferative effects on six tumor cells, which were in concentration-dependent manner.</p>
Subject(s)
Humans , Antineoplastic Agents , Chemistry , Pharmacology , Cell Line, Tumor , Cell Proliferation , Ferns , Chemistry , Flavonoids , Chemistry , Pharmacology , HT29 Cells , Hep G2 CellsABSTRACT
<p><b>OBJECTIVE</b>To study the distribution of hemorrhagic fever with renal syndrome virus (HFRSV) in mites.</p><p><b>METHODS</b>In situ reverse transcription-polymerase chain reaction (IS RT-PCR) was used for detecting the distribution of HFRSV in mites.</p><p><b>RESULTS</b>HFRSV RNA was mainly located in ovary and mid-gut tissues of gamasid mites and chigger mites. The positive signal intensity in the third and fourth generations of gamasid mite was stronger than that in the first and second generations, and that in nymph of chigger mite more than larva.</p><p><b>CONCLUSION</b>Both chigger mite and gamasid mite could play an important role in the transmission of HFRSV.</p>
Subject(s)
Animals , Female , Male , Digestive System , Virology , Hantaan virus , Genetics , In Situ Hybridization , Methods , Mites , Virology , Nymph , Virology , Ovary , Virology , RNA, Viral , Genetics , Metabolism , Reverse Transcriptase Polymerase Chain Reaction , MethodsABSTRACT
Japan has accumulated much mature experience in hospital management, which is worthy of being drawn upon by hospital managers in China. By means of an account of the model of ward rounds by doctors at three levels, the system of academic previews and the system of regular meetings for copying down and reading medical papers in foreign languages in Japanese hospitals and in light of the situation of domestic hospital management, the paper discusses measures for improving the system of ward rounds and scientific research management. The goal is to enhance the medical expertise levels, scientific research capabilities and foreign languages proficiency of medical workers in China so as to deliver better medical and healthcare services to the broad masses of the people.